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The Role of Methadone for Treatment of Addiction

Learn more about the use of methadone for treatment of addiction and how to get the treatment you need.

The opioid crisis continues to be a major global problem. As such, the need for effective treatment strategies has never been more critical.

There are lots of different therapeutic options available. But, among these, the use of methadone for treatment of addiction has emerged as a prominent player.

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Methadone and Addiction Treatment

Methadone is a long-acting synthetic opioid. It is currently widely used as a pharmacological intervention for opioid addiction.

But what exactly does this mean, and how does methadone for treatment of addiction work?

Methadone for Treatment of Addiction

What to Expect from This Article

In this article, we’ll take you through the journey of methadone’s therapeutic use.

We’ll explore what methadone is and the role of methadone for treatment of addiction. We’ll consider the potential benefits of using methadone for opioid addiction treatment. We’ll also evaluate how methadone for treatment of addiction compares to other options.

So what is the role of methadone for treatment of addiction? Let’s get right into it.

Methadone for Treatment of Addiction: What is Methadone?

Methadone is a synthetic opioid medication. It is often used to treat addiction to opioids. This includes both illicit substances like heroin and prescription painkillers such as morphine.

How Methadone Works

As an opioid, methadone works by binding to the opioid receptors in the brain. This means that it can help to suppress the symptoms of opioid withdrawal and reduce cravings.

It can also block the euphoric effects of other opioids, thereby assisting in the treatment of opioid addiction.

Effective, But Addictive

Methadone is an effective tool in the management of opioid addiction. But, it can lead to physical dependence. It also has the potential for misuse.

Because of this, its use should always be monitored by a healthcare professional. It’s also used in some cases for chronic pain management.

Understanding the Use of Methadone for Treatment of Addiction

Methadone plays a crucial role in addiction treatment. Its primary use is in the treatment of opioid addiction.

The use of methadone for treatment of addiction is a strategy known as methadone maintenance therapy (MMT). It has demonstrated considerable success in managing these challenging addictions.

The use of methadone for treatment of addiction operates on two main principles. These are the reduction of withdrawal symptoms and the reduction of cravings for opioids.

Reducing Withdrawal Symptoms

Withdrawal symptoms from opioids can be severe. Affected individuals experience discomforts such as:

  • Muscle aches
  • Restlessness
  • Anxiety
  • Nausea

This is where methadone’s role becomes vital. It helps to reduce the severity of withdrawal symptoms. This makes the recovery process more bearable for patients.

Reducing Cravings

Methadone also helps reduce the intense cravings that people often experience during withdrawal. Because of this, methadone for treatment of addiction makes relapse less likely.

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Prescribing Methadone as Part of a Treatment Plan

The prescription of methadone for treatment of addiction is carried out in a structured, controlled setting. This often involves specialized clinics where the medication is dispensed.

Its use is monitored to ensure safe and effective treatment. This level of oversight is critical given that methadone itself carries a risk of dependency and misuse.

Methadone as Part of a Treatment Plan

The use of methadone for treatment of addiction is not just about the medication itself. It’s part of a comprehensive treatment strategy.

The strategy also includes psychosocial support like counseling. This helps to address the broader issues often associated with addiction.

By addressing these various elements, methadone for treatment of addiction offers a holistic approach to recovery. It provides both symptom relief and a pathway toward a healthier, more stable lifestyle.

Important Note About Methadone Use

It’s essential to note that while methadone is effective in treating opioid addictions, it is not typically used for other substance use disorders, such as alcohol, benzodiazepines, or stimulants. Different medications and approaches are needed to address these types of addictions.

Methadone for Treatment of Addiction: Methadone Mechanism of Action

Understanding the mechanism of action of methadone for treatment of addiction provides crucial insight into its therapeutic benefits.

As mentioned, methadone is a synthetic “opioid.” As such, it interacts with the same receptors in the brain as other opioids, such as heroin or morphine. But, its action differs in two fundamental ways:

  • It’s slower to take effect
  • It remains active for a longer duration

Short-Lived Effects Leading to Withdrawal Symptoms

When a person uses an opioid, the substance quickly binds to the opioid receptors in the brain. This causes a rapid and intense surge of pleasure, also known as a ‘high.’ But, this effect is short-lived.

As the drug leaves the receptors, withdrawal symptoms begin to emerge. This cycle fuels a relentless pattern of use. This is because the withdrawal symptoms can be quite severe.

As such, people will consume more of the substance to avoid withdrawal and to experience the euphoric effect again.

The Value of Methadone in Addiction Treatment

Herein lies the value of methadone for treatment of addiction. Methadone binds to the same opioid receptors, but it does so more slowly and stays active for an extended period—often up to 24 hours.

This slower, longer-lasting action achieves two crucial outcomes in the treatment of opioid addiction.

Decreasing the Intensity of Withdrawal

Methadone helps to lessen the debilitating withdrawal symptoms that occur when a person stops their opioid use.

By occupying the opioid receptors, methadone prevents them from becoming empty. Because of this, it staves off the onset of withdrawal.

Reduces Opioid Cravings

Methadone reduces cravings for opioids. With methadone occupying the opioid receptors, the intense urge to consume opioids diminishes.

Because methadone’s effects are slow and prolonged, it doesn’t cause the euphoric ‘high’ associated with other opioids. This lack of a ‘high,’ combined with reduced cravings, makes illicit opioid use less appealing. This, in turn, assists individuals in their journey to cease opioid use.

It’s important to note that while methadone is a valuable tool in addiction treatment, it doesn’t act as a cure. It’s part of a treatment process.

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Methadone for Treatment of Addiction: Potential Benefits

The use of methadone for treatment of addiction has been studied extensively. Because of this, several significant benefits have been documented.

Some of these benefits include:

Mitigates Withdrawal Symptoms

Methadone helps to reduce withdrawal symptoms that arise from opioid use. These symptoms can range from discomfort, like nausea and muscle aches, to severe anxiety and depression.

By reducing these symptoms, methadone makes the withdrawal process more manageable for those seeking recovery.

Reduces Cravings

Methadone also helps to curb the intense cravings that often accompany opioid addiction. This can improve an individual’s journey to stop opioid use.

Prevents Relapse

The use of methadone for treatment of addiction has been shown to reduce rates of relapse. This is because it helps to reduce withdrawal symptoms and reduce cravings.

Because of this, methadone can help people maintain their abstinence from other opioids.

Enhances Quality of Life

Methadone for treatment of addiction allows people to focus on rebuilding their lives. It offers the opportunity to return to work and reconnect with loved ones.

It also allows people to escape the constant pressure of withdrawal and cravings.

Improves Physical Health

Opioid addiction can have severe physical health consequences. These include an increased risk of infectious diseases like HIV and hepatitis C due to shared needles.

Methadone for treatment of addiction can help mitigate these risks by reducing illicit opioid use.

Promotes Stability

The regular administration of methadone often takes place in a controlled clinical setting. This provides a structured environment that promotes stability and continuity of care.

This can be beneficial for people who may not have had structure or consistency in their lives during their addiction.

Improves Mental Health

Methadone for treatment of addiction can also positively impact mental health. It can help reduce the depression and anxiety often associated with opioid withdrawal.

It can also provide a sense of normalcy that may have been missing during active addiction.

Lifesaving Potential

Methadone for treatment of addiction can save lives. Methadone can decrease the risk of overdose and other life-threatening consequences of opioid addiction.

Potential Risks of Using Methadone for Treatment of Addiction

The use of methadone for treatment of addiction has numerous benefits. But, it also carries potential risks and side effects.

Methadone Dependency

While methadone for treatment of addiction is effective, it is itself an opioid. It can lead to physical dependence.

Over time, people may need higher doses to achieve the same effects. This can potentially cause methadone addiction.

But, this risk can be managed with careful monitoring by healthcare professionals. Gradual dose adjustments and accompanying therapies can also help.

Overdose Risk

Like other opioids, methadone can slow breathing, and an overdose can be fatal. This risk is higher in people who are not tolerant of opioids.

The risk is also high when methadone is used with other substances like alcohol or benzodiazepines. To reduce this risk, people should follow their prescribed dosage. They should avoid mixing methadone with other substances.

They should also seek immediate medical attention if they experience signs of an overdose, such as:

  • Difficulty breathing
  • Extreme drowsiness
  • Slow heartbeat

Side Effects

Methadone for treatment of addiction can cause several side effects. Some of these include:

  • Constipation
  • Sexual dysfunction
  • Sweating
  • Weight gain
  • Sleep disturbances

These side effects can often be managed with dose adjustments, lifestyle changes, or additional medications.

Interactions with Other Medications

Methadone can interact with many other medications, potentially leading to serious complications.

To manage this risk, people should inform their healthcare provider of all medications they are taking. This includes:

  • Over-the-counter drugs
  • Vitamins
  • Supplements

Withdrawal Upon Discontinuation

If an individual decides to stop taking methadone for treatment of addiction, they should do so under medical supervision.

Abrupt discontinuation of methadone can lead to severe withdrawal symptoms. This can be managed by gradually reducing the methadone dose under the guidance of a healthcare professional.


There can be a social stigma associated with the use of methadone for treatment of addiction. This can discourage individuals from seeking or continuing treatment.

This can be managed through education, advocacy, and supportive services to shift societal perceptions and foster understanding of methadone as a legitimate and effective treatment for addiction.

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Other Treatment Options Used with Methadone

The use of methadone for treatment of addiction is most effective when combined with other therapies and support systems.

This holistic approach addresses both the physical and psychological aspects of addiction. It also addresses the social and environmental factors.

Here are the key components often combined with methadone treatment:

Counseling and Psychotherapy

Individual and group counseling are integral parts of comprehensive addiction treatment. They can help people understand the root causes of their addiction.

They can also help them develop healthier coping strategies and work on rebuilding their lives.

Cognitive behavioral therapy (CBT) is particularly useful here. This is because it focuses on changing patterns of thinking and behavior that lead to drug use.

Support Groups

This includes participation in 12-step support groups like Narcotics Anonymous (NA) or Methadone Anonymous. These groups can provide a community of peers who understand the struggles of addiction.

They offer a platform for sharing experiences and receiving mutual support. This can be beneficial during recovery.

Family Therapy

Addiction often affects the whole family, not just the individual. Family therapy can help repair relationships and improve communication. It can also help create a supportive home environment.

It can educate family members about methadone for treatment of addiction and how they can best support their loved one.

Physical Activities and Therapies

Physical activities like yoga and exercise are utilized to help individuals reconnect with their mind and bodies and find release for tension, anxiety, and other triggers.

These activities:

  • Promote physical health
  • Reduce stress
  • Improve well-being

Methadone for Treatment of Addiction

Contact Rockland Recovery Treatment Centers

At Rockland Recovery, we’re committed to providing compassionate and effective addiction treatment services. We understand that reaching out for help is a significant step, and our team is here to guide you through every stage of your journey toward recovery.


Rockland Recovery is a leader in addiction treatment and mental health care. Our multidisciplinary team of top medical experts is committed to addressing the unique needs of each patient. Reach out to us anytime – we are available 24/7.

For additional information or to find addiction treatment and mental health services in your area, contact us directly or visit SAMSHA’s treatment locator. For immediate assistance, call or text 988 to reach the National Suicide & Crisis Lifeline or 855.732.4842 to speak to a Care Coordinator at Rockland Recovery.

Medical Reviewer Kate Perfetti, LADC II

Medically Reviewed by Kate Perfetti, LADC II

Kate is a Licensed Alcohol and Drug Counselor who has worked in the field of substance abuse for the last nine years. At Rockland Recovery, Kate works to provide resources to the local community and engage and progress Rockland Recovery’s alumni program.

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